Supplying cooling agents for the e-liquid industry.
We offer manufacturers a range of the most commonly used cooling compounds for vaping applications. We carry both menthol and non-menthol derived compounds which can be used either standalone or in combination to create a customised cooling effect.
Where do cooling agents come from?
Modern cooling agents started being produced in the 18th century when water-mint was first crossed with spearmint to create peppermint. It is in peppermint that menthol is found and was first isolated.
For almost 200 years after the discovery of menthol all cooling agents were menthol-derived and remained extremely expensive to produce. Then in the 1970s, the Wilkinson Sword company began to research the creation of a range of alternative compounds that could be produced at a lower cost. At the same time, they took the opportunity to try and eliminate some of the drawbacks of menthol-derived compounds.
Most commercially available cooling agents available today came from Wilkinson Sword's research. This is the reason for the "WS" present in their names.
How do cooling agents work?
Cold-sensitive thermoreceptors in the body give rise to the sensations of cooling, cold and freshness. Unsurprisingly, the process is called thermoreception. Different thermoreceptors in the body identify hot and cold sensations and are triggered by different compounds.
This mechanism depends on ion transport across the protein ion channels in the cellular membranes. When a cooling agent comes in to contact with an appropriate thermoreceptor on your tongue (or any internal surface), it de-polarizes the nerve fibers, allowing sodium and calcium into the fibers.
We identify different thermoreceptors (TRPV) according to the temperature-sensitive reception. The TRPM8 (<~28°C) and TRPA1 (<~18°C) channels are activated by cold and that certain types of chemical agonists activate these thermoTRP channels to produce the cooling effect.
Commonly known as Koolada, the WS-3 is one of the most widely used cooling agents on the market. Although it is a derivative of menthol, it is usually classified as a less volatile product with less flavor or odor.
The effect is immediate, with greater intensity than WS-23 (at the same percentage) but its duration is shorter. The sensation of cold that it generates is accentuated in the upper and rear part of the palate and in the part of the tongue closest to the throat.
WS-23 is not derived from menthol but shares the same characteristic of not having odor or flavor and low volatility.
The cooling effect is incremental in its initial stage, taking longer than WS-3 to reach its maximum peak, which doesn't last as long, but it's average cooling effect duration is longer and the sensation drop less pronounced.
Unlike the WS-3, the effect is more present on the front of the mouth and tongue, which in some applications can be translated as a fizzy sensation, similar to carbonation.
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